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Zbl 1215.92020
Dimitrova, Elena; Garc{\'\i}a-Puente, Luis David; Hinkelmann, Franziska; Jarrah, Abdul S.; Laubenbacher, Reinhard; Stigler, Brandilyn; Stillman, Michael; Vera-Licona, Paola
Parameter estimation for Boolean models of biological networks. (English)
[J] Theor. Comput. Sci. 412, No. 26, 2816-2826 (2011). ISSN 0304-3975

Summary: Boolean networks have long been used as models of molecular networks, and they play an increasingly important role in systems biology. This paper describes a software package, Polynome, offered as a web service, that helps users construct Boolean network models based on experimental data and biological input. The key feature is a discrete analog of parameter estimation for continuous models. With only experimental data as input, the software can be used as a tool for reverse-engineering of Boolean network models from experimental time course data.

MSC 2000:: *92C42
92-04 Machine computation, programs (appl. to natural sciences)
62P10 Appl. of statistics to biology
68N99 Software

Keywords: Boolean network; biological model; computer algebra; parameter estimation; reverse-engineering

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