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Monte Carlo estimation of variance component models for large complex pedigrees. (English) Zbl 0739.62081

Summary: Variance component models are widely used in animal and plant breeding. In human genetics, they can be used to identify, among other traits associated with the definition of disease, those that have a significant genetic component in their aetiology. In addition, they can be used in genetic counselling. Most of the methods currently proposed for estimating variance component models often involve repeated inversion of large matrices, resulting in intensive computations, large storage requirements, and numerical instability. Consequently, these methods are restricted to data on nuclear families, to small pedigrees, or to designed pedigrees of simple form.
The authors propose a method for estimating variance component models for large complex pedigrees using jointly the EM algorithm and the Gibbs sampler. The method can handle variance component models with multiple variance components, without the need for repeated inversion of large matrices even on large complex pedigrees. The method is conceptually simple, numerically stable, and easy to implement.

MSC:

62P10 Applications of statistics to biology and medical sciences; meta analysis
65C99 Probabilistic methods, stochastic differential equations
92D10 Genetics and epigenetics
92-08 Computational methods for problems pertaining to biology
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