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Zbl 1188.92017
Qesmi, Redouane; Wu, Jun; Wu, Jianhong; Heffernan, Jane M.
Influence of backward bifurcation in a model of hepatitis B and C viruses. (English)
[J] Math. Biosci. 224, No. 2, 118-125 (2010). ISSN 0025-5564

Summary: In the 1990s, liver transplantation for hepatitis B and C virus (HBV and HCV) related-liver diseases was a very controversial issue since recurrent infection of the graft was inevitable. Significant progress has been made in the prophylaxis and treatment of recurrent hepatitis B/C (or HBV/HCV infection) after liver transplantation. We propose a mathematical model of ordinary differential equations describing the dynamics of the HBV/HCV and its interactions with both liver and blood cells. A single model is used to describe infection of either virus since the dynamics in-host (infected of the liver) are similar. Analyzing the model, we observe that the system shows either a transcritical or a backward bifurcation. Explicit conditions on the model parameters are given for the backward bifurcation to be present. Consequently, we investigate possible factors that are responsible for HBV/HCV infection and assess control strategies to reduce HBV/HCV reinfection and improve graft survival after liver transplantation.

MSC 2000:: *92C50 Medical appl. of mathematical biology
34C60 Applications of qualitative theory of ODE
34D20 Lyapunov stability of ODE
92C60 Medical epidemiology
37N25 Dynamical systems in biology

Keywords: HBV; HCV; transplantation; reinfection; equilibria; transcritical bifurcation; backward bifurcation

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