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Thermodynamics of DNA microarrays. (English) Zbl 1138.92003

Bürger, Reinhard (ed.) et al., Stochastic models in biological sciences. Proceedings of the workshop, Warsaw, Poland, May 29–June 2, 2006. Warsaw: Polish Academy of Sciences, Institute of Mathematics. Banach Center Publications 80, 229-233 (2008).
Summary: DNA microarrays have been widely used in molecular biology laboratories. The main current application of these devices is the determination of the gene expression level for thousands of genes simultaneously. We review a recently introduced physical model for hybridization (i.e., the binding of complementary DNA strands) in Affymetrix arrays and compare it to experimental results. The experimental data follow rather well the microscopic model and the approach offers several advantages compared to traditional methods of microarray data analysis.
For the entire collection see [Zbl 1139.60004].

MSC:

92C05 Biophysics
92C40 Biochemistry, molecular biology
80A10 Classical and relativistic thermodynamics
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