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Zbl 0635.92007
Sen, Asok K.
An application of the Adomian decomposition method to the transient behavior of a model biochemical reaction. (English)
[J] J. Math. Anal. Appl. 131, No.1, 232-245 (1988). ISSN 0022-247X

An approximate analytical solution for the transient phase of the Michaelis-Menten reaction is derived using the Adomian decomposition method. The analytical solution, which is given in the form of a power series, is found to be highly accurate in predicting the behaviour of the reaction in the very early stages. \par To accelerate the convergence of the power series solution and extend its region of applicability throughout the entire transient phase, we have used (a) the method of Padé approximants and (b) the iterated Shanks transformation. Both the Padé approximant and the Shanks transformation are shown to converge rapidly throughout and beyond the transient period and yield very accurate results. A comparison of the various analytical approximations and a direct numerical solution of the nonlinear initial value problem is also presented.

MSC 2000:: *92Cxx Medical topics etc.
65L05 Initial value problems for ODE (numerical methods)
41A21 Pade approximation
92-08 Computational methods (appl. to natural sciences)

Keywords: biochemistry; approximate analytical solution; transient phase of the Michaelis-Menten reaction; Adomian decomposition method; power series solution; iterated Shanks transformation; nonlinear initial value problem

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