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Application of a new processing method to post-LDL-apheresis data. (English) Zbl 1054.92030

Summary: Our aim was to elaborate a method to optimise treatment intervals for individual low-density lipoprotein (LDL)-apheresis treated patients. After each treatment, plasma LDL concentrations show a time-related increase with a decreasing speed until a maximum level. We searched to interpret the post-LDL-apheresis experimental data trend as the physical process that produces the observed curve, so that the fitting presupposed theoretical function is a direct consequence of the physic process, because to establish the better time. Applying the proposed fitting method to a succession of 15 samples obtained from the mean of six plasmaphereses executed on five different subjects, a small estimate standard error (5 mg/dl) and relative error \((1.7 \%)\) with a dispersion evidently related to the experimental error were observed. Obviously, applying the same method to a single case, the dispersion is more marked (relative error \(<5\%)\), with an SE of 10–13 mg/dl, even though the aspect of a casual phenomenon is conserved. Our physical interpretation appears to be a practical model to predict the LDL-rebound kinetics of the single patient.

MSC:

92C50 Medical applications (general)
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