Summary: This paper describes a robust control method using difference signals and multiple competitive associative nets (CAN2s). Using difference signals of a plant to be controlled, the CAN2 is capable of leaning piecewise Jacobian matrices of nonlinear dynamics of the plant. By means of employing the GPC (generalized predictive controller), a robust control method to switch multiple CAN2s to cope with plant parameter change is introduced. We show the effectiveness of the present method via numerical experiments of a crane system.