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Real-time 3D ultrasound guided interventional system for cardiac stem cell therapy with motion compensation. (English)
Fichtinger, Gabor (ed.) et al., Medical image computing and computer-assisted intervention ‒ MICCAI 2011. 14th international conference, Toronto, Canada, September 18‒22, 2011. Proceedings, Part I. Berlin: Springer (ISBN 978-3-642-23622-8/pbk). Lecture Notes in Computer Science 6891, 283-290 (2011).
Summary: This paper describes a clinically translatable interventional guidance platform to improve the accuracy and precision of stem cell injections into a beating heart. The proposed platform overlays live position of an injection catheter onto a fusion of a pre-procedural MR roadmap with real-time 3D transesophageal echocardiography (TEE). Electromagnetic (EM) tracking is used to initialize the fusion. The fusion is intra-operatively compensated for respiratory motion using a novel algorithm that uses peri-operative full volume ultrasound images. Validation of the system on a moving heart phantom produced a landmark registration accuracy of $2.8 \pm 1.45 \,\text{mm}$. Validation on animal in vivo data produced an average registration accuracy of $2.2 \pm 1.8 \,\text{mm}$; indicating that it is feasible to reliably and robustly fuse the MR road-map with catheter position using 3D ultrasound in a clinical setting.