Summary: Desktop grids use the free resources in Intranet and Internet environments for large-scale computation and storage. While desktop grids offer a high return on investment, one critical issue is the validation of results returned by participating hosts. Several mechanisms for result validation have been previously proposed. However, the characterization of errors is poorly understood. To study error rates, we implemented and deployed a desktop grid application across several thousand hosts distributed over the Internet. We then analyzed the results to give quantitative and empirical characterization of errors stemming from input or output (I/O) failures. We find that in practice, error rates are widespread across hosts but occur relatively infrequently. Moreover, we find that error rates tend to not be stationary over time nor correlated between hosts. In light of these characterization results, we evaluated state-of-the-art error detection mechanisms and describe the trade-offs for using each mechanism.