id: 05268911
dt: a
an: 05268911
au: Modchang, Charin; Triampo, Wannapong; Lenbury, Yongwimon
ti: Mathematical model investigations of signal transduction via $G$-protein
    coupled receptors: trafficking and promiscuous coupling of receptors.
so: Proceedings of the international conference on mathematics and its
    applications, ICMA-MU 2007, Bangkok, Thailand, August 15‒17, 2007.
    Bangkok: Mahidol University. 337-347 (2007).
py: 2007
pu: Bangkok: Mahidol University
la: EN
cc: 
ut: promiscuous coupling; trafficking; genetic algorithm
ci: 
li: 
ab: Summary: G-protein-coupled receptors (GPCRs) are a major class of membrane
    protein receptors. GPCRs bind to a variety of extracellular ligands to
    regulate a vast diversity of physiological responses. These receptors
    play a critical role in signal transduction, and are among the most
    important pharmacological drug targets. Upon binding of extracellular
    ligands, these receptor molecules couple to one or several subtypes of
    G proteins which reside at the intracellular side of the plasma
    membrane to trigger intracellular signaling events. The question of how
    GPCRs select and activate a single or multiple G protein subtype(s) has
    been the topic of intense investigations.  We construct a mathematical
    model to investigate promiscuous coupling of receptors to G proteins.
    The model is composed of mass action ordinary differential equations,
    describing ligand-receptor and receptor-G protein interactions,
    receptors synthesis and degradation. In constructing the model, we
    assume that the receptors can exist in multiple conformational states
    allowing for multiple effecter pathways. A genetic algorithm (GA) has
    been implemented to estimate the model parameters. The numerical
    results show some interesting effects, which are qualitatively in good
    agreement with some experimental results.
rv: