id: 05895387
dt: j
an: 05895387
au: Jahangiri, Anila; Durand, Dominique M.
ti: Phase resetting analysis of high potassium epileptiform activity in CA3
    region of the rat hippocampus.
so: Int. J. Neural Syst. 21, No. 2, 127-138 (2011).
py: 2011
pu: World Scientific Publishing Co. Pte. Ltd., Singapore
la: EN
cc: 
ut: hippocampus; CA3; epileptiform; phase-resetting; unit-latency
ci: 
li: doi:10.1142/S0129065711002705
ab: Summary: The theory of phase resetting can reveal important information
    about the dynamic behavior of a periodic system when a single brief
    stimulus is applied to that system at the appropriate time. Phase
    resetting studies have revealed the existence in some biological
    systems of a vulnerable stimulus window generating desynchronization
    and suppression of the activity. The objective of this study was to
    test the hypothesis that a "singular" stimulus could annihilate this
    activity. Perfusion with the high-K solution produced synchronous,
    quasi-periodic population bursts with inter-burst interval of ~0.8-1.5
    seconds. A single 0.1 ms duration anodic pulse of programmable delay
    and magnitude was applied to the somatic layer of the CA3 pyramidal
    cells. Three types of phase-resetting behavior were observed: (1) Weak
    resetting with little or no effect on the timing of the subsequent
    burst, (2) Strong resetting where the applied current pulse delayed the
    next event by one time period, (3) Singular behavior where the applied
    pulse partially or completely suppressed the subsequent bursting. The
    singular stimulus parameter window, however, was very narrow making it
    difficult to generate the singular behavior reliably. Nevertheless, the
    results indicate that singularities exist for high potassium neural
    activity and that a well timed pulse applied with the right amplitude
    can suppress this activity. This study suggests that phase resetting of
    a population of neurons is possible for quasi-periodic interictal
    activity and similar techniques could be applied to the control of
    epileptic seizures.
rv: