id: 05900414
dt: a
an: 05900414
au: Radulescu, Ovidiu; Siegel, Anne; Pécou, Elisabeth; Chatelain, Clément;
    Lagarrigue, Sandrine
ti: Genetically regulated metabolic networks: Gale-Nikaido modules and
    differential inequalities.
so: Priami, Corrado (ed.) et al., Transactions on Computational Systems Biology
    XIII. Berlin: Springer (ISBN 978-3-642-19747-5/pbk). Lecture Notes in
    Computer Science 6575. Lecture Notes in Bioinformatics. Journal
    Subline, 110-130 (2011).
py: 2011
pu: Berlin: Springer
la: EN
cc: 
ut: systems biology; metabolic control; genetic regulation; qualitative
    constraints; univalence property
ci: 
li: doi:10.1007/978-3-642-19748-2_6
ab: Summary: We propose an approach to study static properties of metabolic
    networks with genetic regulation. We base our results on differential
    inequalities which are constraints on the values of the partial
    derivatives of the reaction rate functions. The approach uses an
    iterative elimination method for the steady state equations involving
    algebraic modules that satisfy the Gale-Nikaido global univalence
    property. The same method allows to find conditions for unique steady
    state. In the case of metabolic pathways, partial elimination of
    variables can produce several alternative models, allowing to compare
    steady state changes of metabolites with and without genetic
    regulation.
rv: