\input zb-basic \input zb-ioport \iteman{io-port 05911736} \itemau{Volyanskyy, Kostyantyn Y.; Haddad, Wassim M.; Bailey, James M.} \itemti{Neuroadaptive output feedback control for nonlinear nonnegative dynamical systems with actuator amplitude and integral constraints.} \itemso{Int. J. Adapt. Control Signal Process. 25, No. 6, 483-501 (2011).} \itemab Summary: A neuroadaptive output feedback control architecture for nonlinear nonnegative dynamical systems with input amplitude and integral constraints is developed. Specifically, the neuroadaptive controller guarantees that the control amplitude as well as the integral of the control input over a given time interval are constrained, and the physical system states remain in the nonnegative orthant of the state space. The proposed approach is used to control the infusion of the anesthetic drug propofol for maintaining a desired constant level of depth of anesthesia for noncardiac surgery in the face of infusion rate constraints and an integral drug dosing constraint over a specified time period. \itemrv{~} \itemcc{} \itemut{adaptive control; neural networks; nonnegative systems; nonnegative control; input constraints; saturation; dynamic output feedback; automated anesthesia; electroencephalography; bispectral index} \itemli{doi:10.1002/acs.1201} \end