id: 05611281
dt: a
an: 05611281
au: Qi, Jin-Peng; Shao, Shi-Huang; Shen, Yi-Zhen
ti: Plausible model of feedback-control for cellular response based on gene
    regulatory networks under radiotherapy.
so: Huang, De-Shuang (ed.) et al., Emerging intelligent computing technology
    and applications. 5th international conference on intelligent
    computing, ICIC 2009, Ulsan, South Korea, September 16‒19, 2009.
    Proceedings. Berlin: Springer (ISBN 978-3-642-04069-6/pbk). Lecture
    Notes in Computer Science 5754, 1067-1076 (2009).
py: 2009
pu: Berlin: Springer
la: EN
cc: 
ut: DNA damage; Cellular Network; Radiotherapy; P53
ci: 
li: doi:10.1007/978-3-642-04070-2_112
ab: Summary: In response to genome stresses, cell can trigger its
    self-defensive mechanism by regulating the vital genes and their
    complicated signal pathways. To illustrate the cellular response DNA
    damage under radiotherapy, a plausible feedback-control model of P53
    stress response networks is proposed at single cell level. The kinetics
    of double strand breaks (DSBs) generation and repair, ARF and ATM
    activation, P53-MDM2 regulation, toxins degradation, as well as ion
    radiation (IR) dose feedback-control are presented.
rv: