Summary: We propose using a single mesoscopic ensemble of trapped polar molecules for quantum computing. A ‘holographic quantum register’ with hundreds of qubits is encoded in collective excitations with definite spatial phase variations. Each phase pattern is uniquely addressed by optical Raman processes with classical optical fields, while one- and two-qubit gates and qubit readout are accomplished by transferring the qubit states to a stripline microwave cavity field and a Cooper pair box where controllable two-level unitary dynamics and detection is governed by classical microwave fields.